Technology Development

Predicting post-operative outcome before and during neurosurgery

This patent describes a process of integrating multimodal brain mapping data with behavioral measures of neurocognitive performance, to build patient-specific predictions of post-operative neurologic function, before and during surgery. Brad Mahon, Max Sims, and Hugo Angulo co-founded MindTrace Technologies Inc, in 2020, to turn this technology into a medical device, and bring it into the world at scale. Learn more about MindTrace: www.MindTrace.com

Data processing system for generating predictions of cognitive outcome in patients.  B Mahon, K Parkins, M Sims, B Chernoff, H Angulo-Orquera. US Patent 12,437,878

Predicting how concussion and sub-concussive head hits affect the brain

This patent describes a process of predicting where strain forces accumulate from head hits in an individual's brain, such as occur in some contact sports. MRI is used to build a digital twin of an individual's brain and head. The digital twin captures the distribution of tissue stiffness in the brain, and is provided real-world data from instrumented mouth guards that contain accelerometers. The predictive model builds an accumulative representation of where strain, and hence injury loading, has concentrated in each player's brain. With support of the Chuck Noll Foundation (2025-2028) we are partnering with the CMU Football team to test early applications of this technology. This research and technology development is being led by Dr. Adnan Hirad at the University of Rochester Medical Center.

System for estimating brain injury. B Mahon, A Hirad. US Patent 12,178,591